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How much weight can you lose on Mounjaro?
On average, about a fifth of your body weight at the higher doses, over roughly 17 months. The figure comes from SURMOUNT-1, a trial of 2,539 adults without diabetes.
By Gary Atmos, Penzilla Editorial Team. Last reviewed 8 October 2026.
The numbers by dose
- 5mg: 15.0% average loss. 85 in 100 people lost at least 5%, and 30 in 100 lost 20% or more.
- 10mg: 19.5% average loss. 89 in 100 lost at least 5%, and 50 in 100 lost 20% or more.
- 15mg: 20.9% average loss. 91 in 100 lost at least 5%, and 57 in 100 lost 20% or more.
- Placebo: 3.1% average loss. 35 in 100 lost at least 5%.
All groups also had diet and activity support for the full 72 weeks.
In stones and pounds
Someone starting at 16 stone (about 102kg) who matched the 10mg average would lose a little over 3 stone. Matching the 5mg average would mean about 2 stone 6 pounds. An average hides a wide spread, so your result will differ.
What each dose costs today
The cheapest first order is £120 for 5mg, £193 for 10mg and £224 for 15mg. The move from 5mg to 10mg bought 4.5 more points of weight loss in the trial for £73 more a pen. The move from 10mg to 15mg bought 1.4 points for £31.
Were the trial volunteers like you?
Average starting weight was 104.8kg and average BMI 38. Nobody had diabetes. Everyone received regular diet and activity coaching. If your starting point or support differs, so will your result.
Stopping
SURMOUNT-4 tested what follows. After 36 weeks on Mounjaro, people had lost 20.9%. Those switched to placebo put 14% back on across the following year. Those kept on Mounjaro lost another 5.5%.
Against Wegovy
SURMOUNT-5 compared them: 20.2% on Mounjaro, 13.7% on Wegovy. Wegovy or Mounjaro?
Questions people ask
What is the average weight loss on Mounjaro?
15% to 20.9% of body weight over 72 weeks in SURMOUNT-1, depending on dose.
What are my odds of losing 20% on Mounjaro?
In SURMOUNT-1, 50 in 100 on 10mg and 57 in 100 on 15mg reached 20%.
Does everyone lose weight on Mounjaro?
No. In the trial, 9 to 15 people in 100 lost under 5%, depending on dose.
Do you regain weight after Mounjaro?
In SURMOUNT-4, people who stopped regained 14% of body weight within a year.
Sources
- Jastreboff AM and colleagues, SURMOUNT-1, New England Journal of Medicine, 2022
- Aronne LJ and colleagues, SURMOUNT-4, JAMA, 2024
- Aronne LJ and colleagues, SURMOUNT-5, New England Journal of Medicine, 2025
